TOFI (thin on the outside, fat on the inside) individuals with equal trunk fat but different fat distribution—visceral/intra-abdominal fat versus subcutaneous fat—demonstrate dramatically different metabolic health outcomes; visceral fat is dangerous while subcutaneous fat is protective, making the location and type of body fat more predictive of health than total weight
factualpending
Speaker
Robert LustigEvidence Quote
“two equally weighted people CT scans...trunk fat 12.8 12.8 one's healthy one's sick...subcutaneous fat not dangerous in fact might be protective...intra-abdominal fat...called tofi”
Source
The Subcellular Processes That Belie All Chronic Disease. The Hateful (or Grateful) Eight #lustig— Emery PharmaCreated: 8/10/2026, 10:44:48 PM
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