The optimal IGF-1 range for longevity and health is between 100-250 ng/mL, as this balances benefits of growth factor signaling against risks of tumor growth, hyperglycemia, insulin resistance (at higher levels) and sarcopenia, increased adiposity, and intramuscular triglyceride accumulation (at lower levels), with age-specific adjustments required.
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Speaker
Dr. Kyle GilletteEvidence Quote
“my general rule of thumb is an igf-1 between about 100 and 250 is the Goldilocks zone not so high that you're at risk of tumor growth and hyperglycemia and insulin resistance and not so low that you're at risk of sarcopenia and increased adiposity”
Source
Complete Guide to Peptides for Fat Loss, Muscle Building & Longevity | Dr. Kyle Gillett MD— Thomas DeLauerCreated: 8/13/2026, 4:51:25 AM
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