Melanocortan receptor agonists cause side effects including nausea, increased skin tanning and darkening, and loss of photo-bleaching (natural hair lightening) in blonde individuals, but do not cause downregulation or loss of efficacy with continued use.
factualpending
Speaker
Dr. Kyle GilletteEvidence Quote
“nausea is a side effect for all these and in fact for all of these becoming more tan so a darker skin tone and loss of photo bleaching of the hair”
Source
Complete Guide to Peptides for Fat Loss, Muscle Building & Longevity | Dr. Kyle Gillett MD— Thomas DeLauerCreated: 8/13/2026, 4:51:25 AM
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