GLP-1 suppresses appetite through at least two parallel mechanisms: by acting on intestinofugal enteric neurons to cause gut distension (making people feel full), and by stimulating the hypothalamus through the gut-brain axis to trigger satiety
causalpending
Speaker
Unidentified Speaker — What is GLP-1 & How Does It Reduce Appetite & Promote Weigh… [B8staZOc_xQ]Evidence Quote
“GLP-1 binds to what are called intestinofugal enteric neurons... they cause some gut distension. So they actually make you feel full... So GLP-1 is acting at the level of gut to increase gut distension and by way of a pathway that goes from the gut up to the hypothalamus... is also suppressing appetite through brain mechanisms.”
Source
What is GLP-1 & How Does It Reduce Appetite & Promote Weight Loss? | Dr. Andrew Huberman— Huberman Lab ClipsCreated: 8/11/2026, 1:49:09 AM
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