This Is Extreme! Bryan Johnson's Anti-Aging Skincare Routine

Blue light therapy is specifically helpful for calming acne; it can be used in mask form or as part of full-body systems, though results from at-home masks are more subtle than in-office treatments and require consistent use to maintain effects.

“and the blue light is specifically helpful for calming down acne...you have red light and blue light I've got videos on this as a side note...and then finally let me walk over here and show you this we have uh St red therapy we weren't certain whether it Justified the time I do this uh three times a week uh for 12 minutes so it's a total of uh 36 minutes a week”

A basic effective morning skincare routine consists of: cleanse, moisturize, and apply sunscreen—this is sufficient for foundational skin health and is easy to sustain with minimal irritation risk.

“this is a great morning skincare routine cleanse moisturize sunscreen I mean nothing extraneous I've said this before keep the routine simple and that's easy to stick with less risk of irritation so I really like this routine”

Johnson's advanced skincare protocol requires substantial financial investment in devices, medications, and professional treatments, making it cost-prohibitive for most people and appropriately framed as personal experimentation rather than universal recommendation.

“I guess approach so use discretion hopefully this video of me responding pointing out some of the potential risks of some of these things and what they can and cannot do you know gives you a little bit more background also this is very cost prohibitive for the majority of people out there I can't imagine how much money all this cost”

Exilis is a monopolar radiofrequency device with ultrasound that targets deeper skin layers to cause collagen remodeling and stimulate new collagen production, used on face, neck, and jaw for skin tightening and wrinkle reduction by improving collagen integrity and reducing laxity.

“the exis device is a monopolar radio frequency device with ultra sound and basically what it does is it can be used on the face on the neck and in the Jou are area for like you said skin tightening improving laxity and wrinkles basically it targets the deeper layers of the skin with radio frequency and ultrasound energy to cause remodeling of the collagen and stimulate new healthy collagen to be produced so you get Improvement in tightness and a reduction in overall laxity”

BBL/IPL (Broadband Light or Intense Pulsed Light) is effective at improving hyperpigmentation, redness, telangiectasia (broken capillaries), and may improve papillary dermal collagen, though collagen improvement evidence is mixed; effectiveness depends on device settings, and darker skin tones require careful handling due to risk of thermal injury and post-inflammatory hyperpigmentation.

“intense pulse light or Broadband light however you want to call it it is useful for improving hyperpigmentation redness uh tasas otherwise commonly referred to as broken capillaries on the face I have a video all about that um definitely can improve the appearance of those depending on the settings now you got to be careful if you have a deeper skin tone with this because it does have the risk of burning deeper skin tones causing hyperpigmentation”

A small Stanford study found that intensive pulsed light treatment resulted in genetic expression changes consistent with younger skin at the molecular level, suggesting molecular rejuvenation, though more research is needed to confirm the effect and mechanisms.

“the Stanford study that he's talking about um is interesting I I I looked at it very small like he said um and basically they were they sought out to see if there were any changes on the molecular level you know we can see histologically maybe there's some improvement and sun damage and visible signs of aging either with our eyes or you know under the microscope but they actually want to see are there any differences in the genes that are being expressed and and like he says it kind of the research kind of suggested that with intense pulse light you get genes being expressed that are more characteristic of like a younger skin so it kind of does suggest some degree of you know molecular Rejuvenation but again more research is needed”

Multispectral imaging is a clinical-grade measurement tool that reads spectral and spatial data from multiple skin chromophores (melanin, oxyhemoglobin, deoxyhemoglobin, collagen, water) and provides 8-10 objective biomarkers of skin damage including hyperpigmentation, dark spots, moles, and sun damage, but has limitations and does not capture all relevant skin parameters like subcutaneous fat volume.

“multispectral Imaging is a tool that basically allows for collecting spectral Imaging and spatial data kind of all at once and essentially what it's doing is reading information from various chromophores in your skin mostly melanin as well as oxy and deoxyhemoglobin collagen water so it really gives the to the technology information that kind of gives you some insight into things like hyperpigmentation dark spots moles”

Johnson is taking rapamycin (sirolimus), an immunosuppressant used for organ transplant rejection prevention, which also has anti-proliferative and anti-angiogenic properties; the bulk of anti-aging research supporting its use is preclinical (animal and in vitro models), with limited human studies showing improved immune function in older adults but insufficient evidence in otherwise healthy people.

“he's taking um rrap sense so this is a drug that is actually an immunosuppressant meaning it lowers the immune system and because of that it's given to patients who have had an organ transplant to prevent them from rejecting the transplanted organ it also has some other beneficial properties for certain indications it is anti-proliferative and it has anti-angiogenesis properties”

UV exposure comes through standard window glass (specifically UVA rays, not UVB which is mostly blocked), and sustained exposure in rooms with large windows can accumulate significant UVA exposure over time, particularly in sunny climates.

“yes sun does come through window glass UVA rays specifically most window glass will block out UVB the Rays that burn the skin but UVA does come through window glass now your exposure to that is going to vary depending on the time of the day where you live and how close you're sitting to the window but he has some pretty big Windows lives in a very sunny climate so yeah overtime that is quite a bit of UVA um enough to you know if you spend a lot of time in that room maybe you'd want to be wearing sunscreen indoors for sure”

Blueprints's protocol for diet involves a targeted caloric intake of 2,250 calories per day where every calorie is required to have measurable benefit (hitting specific biomarkers for organ health) or it is removed from the diet; the same principle applies to skincare interventions measured by objective markers.

“it's like food where we've constructed a diet for my 2,250 calories where every calorie has to fight for its life so we have these ideal markers of where we want the organs to be and we have the food and if the food does not deliver the marker that we expect it to it's out the same is kind of true with the clinic where we have these markers for example with skincare like UV damage pore size Reds Browns Etc if we don't hit the markers the technology is out”

Brian Johnson has window tinting on his house windows that blocks approximately 99.9% of UV radiation to minimize sun exposure indoors, citing the objective of slowing aging speed and reversing aging damage rather than adhering to cultural aesthetic norms of tanned skin.

“on my windows I have really big ones all over the house and I get a lot of sun in the morning at night and so to control the environment we have a tint on here that knocks out like 99.9% of UV I get a lot of comments about my pel skin I'm a vampire that's what I'm trying to do okay but really Sun causes damage it ages your skin it makes you look older so you don't want that and what the objective of blue blint is not to adhere to cultural norms of a tan the the objective is slowing my speed of aging and reversing aging damage that includes sun damage”

Brian Johnson attempts to measure the effects of interventions by testing them on a fixed schedule (e.g., three weeks for each cream), evaluating whether they move objective markers; if treatments do not produce demonstrable improvements in markers, they are discontinued from his protocol rather than continued out of assumption or tradition.

“I just applied this at of poo cream uh we've been trying this now for 3 weeks like we do with every cream we're motivated to see does this work by the markers we can measure...we're not doing it anymore because it's got to prove that it's worthy of existence in the protocol otherwise it's out”

Johnson paused use of Exilis radiofrequency device due to concern that incorrect temperature settings (above 40-42°C) can cause fat loss rather than restoration, which conflicts with his goal of face volume rejuvenation; this demonstrates appropriate caution with unproven device applications.

“we have a device uh that measures heat we stay at exactly 40 to 42c anything above is used for fat burning but anything below uh should be restorative but just out of precaution because we're trying to rejuvenate volume we've paused this device so it's pending future analysis in the hands of someone who knows how to operate the device and the correct settings definitely not a concern”

An age reader (fluorescence-based AGE reader) measures AGE fluorescence but has limitations in truly quantifying AGEs; it may be helpful in research settings but is not necessarily the best tool for precise quantification of AGE burden.

“the tool he is um talking about is an age reader and basically this um works by measuring fluorescence uh my understanding is it's kind of helpful and maybe a research setting but it definitely has its limitations and it's not necessarily the best tool for truly quantifying these but does give you some information”

Johnson achieved substantial measured skin age improvement over one year through his protocol, moving from approximately 98th percentile (worst) to normal range, with skin age biomarker improving from ~64 to 37-42 years.

“I'm very happy with the progress we've made looking at my damage I think when I started I was in like a 98 percentile U my skin age was like 64 on one of the markers and I'm back on my recent measurement I was I think to between 37 and 42 so had significant improvements in the measurement”

Brian Johnson was very concerned about whether radiofrequency or similar devices justified the time investment of his protocol and has recently become 'very positive' on the Tixel thermal-mechanical ablation technology; he is currently purchasing a Tixel device for his clinic after evaluating it as safe and efficacious.

“we didn't yet own the device we're buying it now but that uses thermal mechanical oblation so it uses a titanium tip and it delivers these these intense pulses of heat and we found it is safe so we've used laser we use RF and they all have these pros and cons there's always some nuances with the technology tixel refining is safe it's efficacious it does the same things like uh firmness and collagen production so I'm now three Therapies in we like the results so far”