How To REDUCE HISTAMINE Inflammation in 12 Weeks

The diamine oxidase (DAO) pathway is the modern biochemical term for what was historically called histaminase and breaks down histamine in the GI tract and elsewhere in the body; it is supported by vitamin C, B6, B1, magnesium, and copper.

“if you go back 25 30 40 years we used to have an enzyme the second enzyme we call a histaminase in modern times you hear about Dao or diamine oxidase that is the same thing histaminase became diamine oxidase because it's more of an appropriate biochemical term but that is the enzyme Pathway to break down histamine it's heavily represented in your GI tract but it's also expressed elsewhere in the body so you can support acetylation through vitamin B5 you can support diamine oxidase through things like vitamin C and vitamin B6 and B1 and magnesium and a little bit of copper”

Upstream triggers for pathological histamine release include Mast Cell Activation Syndrome, chronic infections, poor digestion, inappropriate microbiome composition, and toxicities.

“Mast Cell problems can do it chronic infections can trigger these things very common poor digestion and inappropriate microbiome in your gut can trigger these things as well toxicities can trigger these things and any number of other things”

Excess histamine in the brain can trigger headaches, anxiety states, and even psychotic episodes.

“if you give the brain too much histamine it can trigger a lot of things such as headaches anxiety States even psychotic episodes”

The acetylation pathway breaks down histamine and is supported by vitamin B5 (pantothenic acid), which has been used for decades in integrative medicine to help with histamine issues and acts as a 'relief valve'.

“there is an acetylation pathway that runs through an acetyl transferase and thankfully that is supported by vitamin B5 often known as pantothenic acid and for decades in the Integrative Health community physicians have used vitamin B5 to help with histamine issues now it's not the only way out but vitamin B5 is General very well tolerated and it can be a I call it kind of the relief valve”

The second intervention for high histamine states is to attend to all three elimination pathways for histamine; this requires supporting acetylation (B5), DAO (C, B6, B1, Mg, Cu), and HMNT (methyl donors, MAO cofactors, aldehyde-clearing cofactors).

“number two is to attend to the three elimination Pathways for histamine biochemically in your body now what are these three Pathways there is an acetylation pathway that runs through an acetyl transferase and thankfully that is supported by vitamin B5”

The third intervention is understanding the upstream triggers that cause mast cells and other cells to release histamine pathologically, beyond simple allergic responses.

“number three is more understanding why histamine can be such a problem so there's a lot of other reasons for histamine to give us health problems other than we might just be a little allergic or a lot allergic to pollen or something that's certainly one reason right but there's a lot of Upstream triggers to the cells that release histamine”

Chronic illnesses characterized by chronic infections, toxicities, gut dysbiosis, microbiome problems, or biofilm formation must be identified and addressed as underlying drivers of histamine symptoms; dietary restriction and pathway support alone will not resolve the problem if these root causes are present.

“if you have a chronic illness that you may not know about or you do know about and it has characteristics of chronic infections or toxicities or gut problems microbiome problems biofilms Mast Cell Activation issues those have to you know you need to know that part one and two lower the histamine in your diet improve the elimination of histamine can really help but if you still are having problems we've got to tackle big number three which is what else is triggering histamine in my system”

Peripheral histamine causes allergies, hay fever, itchiness, hives, anaphylactic syndrome, and can also create joint pain and other unpleasant conditions.

“peripheral histamine we think of giving us you know allergies hay fever symptoms itchiness hives even allergy anaphylactic syndrome but also histamine can create joint pain and other unpleasant things”

Histamine is a signaling molecule used in the brain and throughout the body, and removing all histamine from the brain would cause death because the body's regulatory mechanisms run on histamine receptors.

“histamine is a signaling molecule that is used both in the brain and through your entire body to Signal different types of activity if we took all the histamine out of our brain we would die because our bodies regulatory mechanisms that run on histamine receptors would just shut off”

Mast Cell Activation Syndrome (MCAS) is a condition where cells that release histamine and other inflammatory chemicals become oversensitive and release their contents prematurely and inappropriately.

“those things then can be Mast Cell Activation Syndrome which means that the cells that release histamine and other inflammatory chemicals are too sensitive and they release the chemicals prematurely and they shouldn't be doing it”

Histamine aldehydes are toxic intermediate forms that do not cause typical allergic symptoms (hives, runny nose) but instead create general toxicity symptoms like headaches and malaise, particularly when metabolic conversion is blocked at the aldehyde stage.

“aldehydes of histamine are also very disturbing to your body they're an intermediate toxic form aldehydes don't usually make you have the hives or runny nose or other stuff aldehydes plain make you feel toxic you can have headache syndromes and other stuff if you're trapped at the aldehyde level”

The histamine N-methyltransferase (HMNT) pathway is long and complex: it requires methyl donors (methyl B12, methylfolate), then monoamine oxidase (MAO) to convert methyl histamine into an aldehyde, which is itself toxic and requires aldehyde enzyme support (B6, Mg, C, B1 thiamine, and B3 niacinamide/NAD cofactors) to clear.

“you've got a long winding pathway often referred to as the hmnt pathway so that pathway doesn't just have one end enzyme so in people that are real sensitized what I will normally do is start with the acetylation pathway through vitamin B5 and the Dao pathway either through Dao supplement or the cofactors and that kind of takes some of the pressure off it helps the histamine move out and then the long and winding pathway the histamine and methyl transferase pathway is a little tricky because the first step uses a methyl donor like methyl B12 methylfolate but some people say well I take that and I get worse histamine symptoms well the reason for that is that once I take histamine and I methylate it methyl histamine and some of my receptors can bind harder than regular histamines I call evil histamine it's an intermediate”

The first intervention for high histamine states is to identify and remove high-histamine or high-histamine-triggering foods from the diet; universities publish histamine-containing food lists scaled by level (low, medium, high or grade one to five).

“the first one if you are truly suffering from high histamine States is to look at histamine triggering or high histamine foods and remove those from your diet now in the olden days we used to have these books or handouts or whatever that we would give people or mail to them now you can go online and while not every list will agree of what's higher lower histamine if you find a reputable online Source many universities have you know histamine containing food lists and they'll list a scale low medium high or grade one to five something like that”

Methyl histamine (the intermediate product of methylation) can bind more strongly to histamine receptors than regular histamine, and is referred to as 'evil histamine'.

“once I take histamine and I methylate it methyl histamine and some of my receptors can bind harder than regular histamines I call evil histamine it's an intermediate”

Monoamine oxidase (MAO) is the biochemical cousin of diamine oxidase (DAO) and is supported by similar cofactors: vitamin B6, magnesium, and vitamin C.

“monoamine oxidase the cousin of Dao is Mao okay so monoamine oxidase takes methyl histamine and much like Dao does on the other side it converts it down to a different chemical”