
Brain Really Uses Quantum Effects, New Study Finds
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When Roger Penrose originally came out with the idea that the human brain uses quantum effects in microtubules and that was the origin of consciousness, many thought the idea was a little crazy. According to a new study, it turns out that Penrose was actually right… about the microtubules anyways. Let’s have a look.
Paper: https://pubs.acs.org/doi/10.1021/acs.jpcb.3c07936
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Recent experimental evidence demonstrates that microtubules display quantum effects (superradiance) at room temperature, lending empirical support to the theoretical plausibility of Penrose-Hameroff's quantum consciousness hypothesis, though significant logical gaps remain between quantum effects in the brain and consciousness itself.
- New research shows microtubules exhibit superradiance—a quantum effect requiring quantum links between molecules—both theoretically and experimentally at room temperature
- This quantum robustness to environmental noise is unexpected and contrasts with the traditional objection that warm, noisy brains cannot sustain quantum effects
- However, the mere presence of quantum effects in brain cells does not explain how they generate consciousness
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A new research paper from a group independent of Penrose and Hameroff provides experimental evidence that microtubules display real quantum effects, specifically a process called superradiance, which requires molecules to have quantum links to each other to achieve larger light emission.
“Now comes this new paper from a group that doesn't seem to have anything to do with either Penrose or Hameroff and they say that they've cleared evidence that these microtubules actually do display real quantum effects. More specifically, it's a process called superradiance. It basically requires the molecules to have quantum links to each other to achieve a larger emission of light.”
The quantum superradiance effect observed in microtubules was demonstrated at room temperature and appears to be robust against environmental noise, which is unexpected given that quantum effects typically decohere rapidly in warm, noisy environments.
“They didn't actually test it in a cell, just in a solution, but it's at room temperature and they say the superradiant effect basically doesn't care about the environmental noise. This is very interesting, just because it's an example for quantum enhanced effect that seems to be unexpectedly robust.”
In addition to enabling superradiance, quantum effects in microtubules make them much more efficient at absorbing ultraviolet light and redistributing it to lower energies, which protects cells from potential harm caused by ultraviolet radiation.
“Another interesting part of the paper is that they say that the quantum effects in these microtubules can do something else, which is that they become much more efficient at absorbing ultraviolet light and redistributing it to lower energies. That is, they basically protect cells from the potential harm of ultraviolet light.”
A major problem with Penrose's quantum consciousness hypothesis is that the human brain is warm and noisy, environmental conditions that are generally hostile to quantum physics, unlike quantum computers which require suspension from multiple shock absorbers and cooling to millikelvin temperatures to preserve quantum effects.
“The problem with this idea, as many physicists have pointed out, is that the human brain is a warm and noisy place and they are generally not very welcoming to quantum physics. That's the reason that current day quantum computers are suspended from three levels of shock absorbers and cooled to a few millikelvin. It's not just because it looks impressive, though that is that, it's because otherwise the quantum effects just go away too quickly to do any computing with them.”
For Penrose's quantum consciousness hypothesis to be viable, quantum effects would need to survive in the human brain long enough for a neuron to fire, but the human brain fires extremely slowly, and even basic estimates show this timescale is insufficient for quantum effects to persist.
“For Penrose's idea to make any sense, you'd have to have quantum effects survive in the human brain at least until a neuron has managed to fire and the human brain is ridiculously slow in its firing. Even the most basic estimates say that it wouldn't work out.”
There is a significant logical gap between the empirical observation that quantum effects exist in microtubules and the theoretical claim that quantum effects generate consciousness; the presence of quantum effects in brain cells does not necessarily imply those effects create consciousness.
“What does any of this have to do with consciousness? Nothing, really. The last time I looked, we did need brain cells for consciousness. There seems to be a big logical gap between there are quantum effects in human brains and quantum effects create consciousness.”
Microtubules are large molecules that form a central part of all cells in the human body and play a significant role in signal transport in the human brain, composed of polymers that combine into tubes made of smaller components called tubulin.
“Microtubules are big molecules, basically. They're a central part of all cells in the human body and play a big role for signal transport in the human brain. They're polymers that combine to tubes and are made of smaller components called tubulin.”
The research group that discovered quantum effects in microtubules first built a computer model of how tubulin molecules combine to form microtubules and how they absorb light, then tested this model in the laboratory and found good agreement between theoretical predictions and experimental results.
“They first built a computer model for how the tubulin molecules combine to microtubules and how they would absorb light. Then they also tested this in the laboratory and they found good agreement, both theoretically and experimentally.”
The research establishing quantum effects in microtubules did not test these effects in living cells, only in laboratory solutions, which means the biological relevance of these findings remains to be established.
“They didn't actually test it in a cell, just in a solution, but it's at room temperature”
Roger Penrose proposes that consciousness cannot be explained by computable processes and therefore requires an uncomputable element, which he hypothesizes is the collapse of the wave function in quantum mechanics occurring in the human brain.
“Roger Penrose now has this idea that consciousness can't be explained by a computable process. So, there needs to be an uncomputable element in what the brain does and that he says can be the collapse of the wave function in quantum mechanics. The collapse is when a quantum distribution of possibilities collapses to one actuality. His hypothesis is that this happens in the human brain and that's what creates conscious thought.”
The reason Penrose locates the non-computable element in wave function collapse rather than elsewhere is that all other known brain processes are computable, making wave function collapse the only remaining place to hide something non-computable.
“Why the collapse of the wave function? Because we know that all the rest is computable, so that's the only place you can hide something non-computable.”
Stuart Hameroff, a neurobiologist, proposed that microtubules could serve as the specific location where quantum effects sufficient for consciousness arise, suggesting that microtubules can synchronize due to quantum effects, thereby allowing quantum effects to persist long enough to play a role in conscious thought.
“Penrose originally didn't say anything about specifically how these quantum effects should come about in the human brain, but he later teamed up with Stuart Hameroff, a neurobiologist who had this idea that it would be microtubules. The microtubules, Hameroff convinced Penrose, can basically synchronize due to quantum effects and that helps the quantum effects survive for long enough to play a role in conscious thought.”
Large language models are currently dominated by English-language text, which the speaker believes is problematic because speaking in different languages with different grammar and vocabulary structures provides different perspectives of the world.
“I recently read a paper saying that large language models are currently totally dominated by English language text. It bothers me because I believe that speaking in a different language with different words and different grammar does give you a somewhat different view of the world.”
Both Roger Penrose and Stuart Hameroff are intellectually rigorous and not unintelligent despite pursuing ideas that many consider speculative or 'crazy.'
“I've met both Penrose and Hameroff and they're both crazy, of course, but neither of them is stupid.”
The speaker expresses skepticism about the researchers' claim linking quantum effect failure to degenerative brain diseases, acknowledging this is outside their research expertise.
“I'm somewhat skeptical about this, but then this isn't my research area.”
The researchers suggest that if quantum effects in microtubules fail or are impaired, this might contribute to the etiology of degenerative brain diseases.
“In the press release, the researchers say if these quantum effects fail, that might play a role for degenerative brain diseases.”
The quantum computing community may attempt to leverage the robust superradiance effect observed in microtubules for quantum computing applications.
“I'd be surprised if not the quantum computing people will try to use it.”